This study also demonstrates the capabilities of MicroED for structure-based drugdesign.
2
These results provide a mechanistic foundation for future aGPCR-targeted drugdesign.
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It is likely to prove useful for protein and drugdesign.
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More generally, these findings provide a basis for a novel drugdesign platform.
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XtalPi uses AI, cloud computing and quantum physics to improve drugdesign processes.
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These findings have implications for the rationaldesign of new electrosurgical instruments.
2
This calls for rationaldesign of enzymes capable of catalyzing their biotransformation.
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These findings will aid in the rationaldesign of future immunotherapy clinical trials.
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For rationaldesign of new vaccine candidates, correlates of protection are highly desirable.
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This inhibitor-binding-induced pocket presents an opportunity for the rationaldesign of PfHT1-specific inhibitors.
Uso de rational drug design en inglés
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I'm a believer in this what you call rationaldrugdesign.
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A recent trend toward more rationaldrugdesign was observed.
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The discovery of these agents has not always been the result of rationaldrugdesign.
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This advanced in silico approach is valuable to achieve rationaldrugdesign of selective G4 binders.
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Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rationaldrugdesign.
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A rationaldrugdesign should take this into account for screening molecules with improved permeation properties.
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Recent findings: Within the last year, exome-wide analyses have highlighted key mutations to guide rationaldrugdesign.
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These results provide an avenue for understanding ligand modulation of the AhR functionality and for rationaldrugdesign.
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Information derived from these studies will facilitate rationaldrugdesign and the selection of complementary anti-HIV drugs for combination therapy.
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These structures provide a foundation for rationaldrugdesign of small molecule inhibitors to be used in prevention of invasive streptococcal disease.
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In summary, this study provides insight into the ligand binding mode of GnRH1R and offers an atomic framework for rationaldrugdesign.
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This technique represents a new method to assay drug translocation inside the cell and therefore incorporate rationaldrugdesign to impact antibiotic uptake.
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Predicting the three-dimensional structure of ligand-receptor complexes involving G protein-coupled receptors (GPCRs) is still a challenging task in rationaldrugdesign.
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This study provides new information on the three-dimensional nature of the endothelin A receptor binding site which may prove useful for rationaldrugdesign.
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The contributions of quantitative structure-activity relationship (QSAR) models derived from the classical and comparative molecular field analysis (CoMFA) approaches to rationaldrugdesign were examined.